A great SUV, with a few very expensive weaknesses
The 2000 year model has a known auto transmission failure issue. Some seem to run forever, but many trannies fail and Lexus has never admitted this issue. It appears that some planetary gear cases (aluminum) fail and grind out shavings, total failure. Dealer price for rebuilt unit runs around $4,500. Year model 2001 on replaced this part with steel, ending the problem. Auto door locks and power window systems fail for repair costs of $500 or more per door. My belief is plastic electric plug connector failures, common on many makes, but drivers usually replace electro mechanical components instead of checking this item. I fixed my cruise control with a bit of electrolytic grease in the under-hood plug. $1.95 instead of hundreds. A great vehicle, I have 173,000 miles on mine and love it. Huge recall for early model oil channels too small. Many short blocks replaced free by Lexus due to engine oil sludge total engine failure. Do not neglect checking fan belts, timing belt and water pump, hoses, proper lubes.
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